- Combined hepatocellular and cholangiocarcinoma
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Jung Hyun Kwon, Si Hyun Bae, Jung Pil Suh, Ho Sung Park, Chan Ran You, Jong Young Choi, Seung Kew Yoon, Dong Hoon Lee, Ho Jong Chun, Byung Gil Choi, Chan Kwon Chung, Eun Sun Jung, Mi Ryung Ryu
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):49-54. Published online June 30, 2007
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Abstract
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- A 43 year-old-women patient was admitted for one month of jaundice. She was diagnosed hepatitis B carrier
17 years ago and has not done a routine check. Abdominal CT showed a large ill defined mass in left hepatic lobe
with inhomogenous enhancement in arterial and delayed phase. The result of biopsy including the
immunohistochemical stains showed the combined hepatocellular and cholangiocarcinoma (stage IVa, type C by
Allen and Lisa). With the radiation therapy (3,910 cGy), six times of transarterial chemo-lipiodolization and two
times of percutaneous ethanol injection, huge mass was markedly decreased in size and no stain in hepatic
angiogram. She underwent left lobectomy.
- Small Hepatocellular Carcinoma in Dysplastic Nodule
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Chang Wook Kim, Eun Sun Jung, Jong Young Choi, Jeong Won Jang, Si Hyun Bae, Seung Kew Yoon, Chang Don Lee, Kyu Won Chung, Hee Sik Sun
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Journal of the Korean Liver Cancer Study Group. 2004;4(1):50-54. Published online June 30, 2004
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Abstract
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- Dysplastic nodule (DN) is considered as precancerous lesion of hepatocellular carcinoma (HCC). There are several evidences to support the theory about multistep progression of hepatocarcinogenesis. Recently we experienced a patient with HCC of the
odule-in-nodule pattern, namely small HCC within DN, which supported the multistep theory of hepatocarcinogenesis. The tumor was seen as a 3 cm, arterial enhancing mass with delayed wash-out patterns in the segment Ⅶ at helical CT. The patient was treated by surgical resection. A 3.0×2.5 cm mass was seen in the resected specimen. A 2.2×1.5 cm, smaller nodule was observed within this mass, i.e. the
odule-in-nodule pattern. Microscopically, various grades of HCC foci were seen within high grade DN. Because DN does not always progress to HCC, further studies are needed to evaluate what kind of DN has the high possibility of progressing of HCC at last.
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